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Stemcell 72284 Trichostatin A
Product Overview
Trichostatin A is a potent and reversible inhibitor of Histone Deacetylase (HDAC), therefore acting as an epigenetic modifier by preventing the removal of acetyl groups from lysine residues on histone tails. Trichostatin A inhibits both class I and class II HDACs, including HDAC1 (IC₅₀ = 6 nM), HDAC4 (IC₅₀ = 38 nM), and HDAC6 (IC₅₀ = 8.6 nM). (Furumai et al., Yoshida et al.)
REPROGRAMMING
· Increases the reprogramming efficiency of mouse embryonic fibroblasts to induced pluripotent stem (iPS) cells (Huangfu et al.).
· Resets epigenetic memory in mouse iPS cells, in combination with 5-Azacytidine (Kim et al.).
·Increases the efficiency of cloned mouse embryo development by somatic cell nuclear transfer (Kishigami et al.).
MAINTENANCE AND SELF-RENEWAL
· Prevents dedifferentiation of primary rat hepatocytes in culture, maintaining liver-specific cellular functions (Henkens et al.).
DIFFERENTIATION
· Promotes differentiation of hepatocytes from human mesenchymal stem cells (Snykers et al.).
CAS Number:58880-19-6
Alternative Names:TSA
Chemical Formula:C₁₇H₂₂N₂O₃
Molecular Weight:302.4 g/mol
Purity:≥ 98%
Pathway:Epigenetic
Target:HDAC
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