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Stemcell 73512 TWS119
Product Overview
TWS119 is a potent disubstituted pyrrolopyrimidine inhibitor of glycogen synthase kinase 3 beta (GSK3β) with an IC₅₀ of 30 nM and Kd of 126 nM (Ding et al.). GSK3 is a serine/threonine kinase that is a key inhibitor of the WNT pathway; therefore TWS119 functions as a WNT pathway activator.
MAINTENANCE
· Maintains the bi-potent, quiescent state in hepatic stellate cells of Wistar rats (Kordes et al.).
DIFFERENTIATION
· Induces differentiation of mouse embryonal carcinoma and embryonic stem cells to neurons (Ding et al.).
· Induces production of T memory stem cell-like (T-SCM) cells from mouse or human CD8+ T cells with evidence of increased persistence, proliferation, and anti-tumor activity after adoptive transfer of mouse-derived T-SCM (Forget et al.; Gattinoni et al.).
CANCER RESEARCH
· Inhibits cell proliferation and induces apoptosis in human alveolar rhabdomyosarcoma cells (Zeng et al.).
CAS Number:601514-19-6
Alternative Names:GSK 3B Inhibitor XII
Chemical Formula:C₁₈H₁₄N₄O₂
Molecular Weight:318.3 g/mol
Purity:≥ 90%
Pathway:WNT
Target:GSK3β
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