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Stemcell 73534 Vandetanib
Product Overview
Vandetanib is a multi-kinase inhibitor, targeting primarily receptor tyrosine kinases, such as vascular endothelial growth factor receptors (VEGFR1, KDR, and FLT4), epidermal growth factor receptor (EGFR), and fibroblast growth factor receptor (FGFR; Morabito et al.). It most potently inhibits KDR with an IC₅₀ of 40 nM. It also inhibits non-receptor tyrosine kinases such as RET, ABL, and SRC as well as several serine/threonine kinases (Hennequin et al.; Carlomagno et al.; Kiselyov et al.; Levinson & Boxer).
CANCER RESEARCH
· Inhibits tumor growth in mouse xenograft models, including RET/PTC papillary thyroid carcinoma and lung carcinoma (Hennequin et al.; Carlomagno et al.).
· Inhibits angiogenesis, cell growth and metastasis in numerous cancer cell lines (Morabito et al.; Wedge et al.).
CAS Number:443913-73-3
Alternative Names:Caprelsa™, CH 331, Zactima, ZD 6474
Chemical Formula:C₂₂H₂₄BrFN₄O₂
Molecular Weight:475.4 g/mol
Purity:≥ 98%
Pathway:酪氨酸激酶
Target:ABL; EGFR; FGFR; FLT4; KDR; RET; SRC; VEGFR1
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