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Stemcell 73542 WHI-P131
Product Overview
WHI-P131 is an inhibitor of Janus kinase 3 (JAK3) with IC₅₀ values of 9 and 78 μM against human and mouse proteins, respectively (Sudbeck et al.). It has also been reported to show significant inhibition of other kinases, including epidermal growth factor receptor (EGFR) in the nanomolar range (Changelian et al.; Uckun et al.). No significant inhibition of JAK1 or JAK2 has been observed (Sudbeck et al.).
CANCER RESEARCH
· Induces apoptosis and cell death in human glioblastoma cell lines U373 and U87 (Narla et al.).
IMMUNOLOGY
· Inhibits lipopolysaccharide (LPS)-induced nitric oxide synthase expression and nitric oxide production in macrophages (Sareila et al.).
MAINTENANCE
· Inhibits proliferation of neural stem cell-containing neurospheres at lower concentrations than the concentration required to inhibit proliferation of astrocyte cultures (Diamandis et al.).
CAS Number:202475-60-3
Alternative Names:Janex-1
Chemical Formula:C₁₆H₁₅N₃O₃
Molecular Weight:297.3 g/mol
Purity:≥ 98%
Pathway:JAK/STAT
Target:JAK3
Related products
Description | Catalog # | Format |
WHI-P154, 10 mg | 73552 | 10 mg |
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WHI-P131 , 1 mg | 73542 | 1 mg |
Waste Bags, Liquid Handler, 100 pack | 23103 | 1 EA |
Warranty Re-Instatement Fee | 20208 | 1 EA |
Vitronectin XF Kit | 07190 | 1 Kit |
Vitronectin XF | 07180 | 250 µg/mL |
Ventral Mesencephalon Neurospheres,1vial | 00332 | 1 vial |
Vandetanib, 100 mg | 73534 | 100 mg |
Vandetanib, 10 mg | 73532 | 10 mg |
Valproic Acid (Na Salt), 500 mg | 72292 | 500 mg |
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