- 产品详情
- 产品参数
- 产品评论
Stemcell 72672 XAV939
Product Overview
XAV939 is a potent, small molecule inhibitor of tankyrase (TNKS) 1 and 2 (IC₅₀ = 11 and 4 nM, respectively) (Huang et al.). By inhibiting TNKS activity, XAV939 increases the protein levels of the axin-GSK3β complex and promotes the degradation of β-catenin in SW480 cells (Huang et al.), thereby inhibiting WNT pathway downstream actions.
DIFFERENTIATION
· Induces cardiomyogenesis in mesoderm progenitor cells derived from mouse embryonic stem cells (Wang et al.).
· In combination with the SMAD inhibitors LDN193189 and SB431542, promotes induction of forebrain fates in human pluripotent stem cell lines (Maroof et al.).
CANCER RESEARCH
· Inhibits colony formation of APC-deficient, β-catenin-dependent DLD-1 colorectal cancer cells (Huang et al.).
CAS Number:284028-89-3
Alternative Names:Not applicable
Chemical Formula:C₁₄H₁₁F₃N₂OS
Molecular Weight:312.3 g/mol
Purity:≥ 98%
Pathway:WNT
Target:TNKS
Related products
Description | Catalog # | Format |
Zoledronic Acid, 50 mg | 73572 | 50 mg |
Zebularine, 10 mg | 72902 | 10 mg |
Y-27632 (2HCl), 50 mg | 72307 | 1 Kit |
Y-27632 (2HCl), 50 mg | 72308 | 50 mg |
Y-27632 (2HCl), 5 mg | 72304 | 5 mg |
Y-27632 (2HCl), 1 mg | 72302 | 1 mg |
XAV939, 10 mg | 72674 | 10 mg |
XAV939, 1 mg | 72672 | 1 mg |
Uante,您的科研物资战略合作伙伴！
重庆市寰宇安泰生物科技有限公司