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Stemcell 72902 Zebularine
Product Overview
Zebularine, a cytidine analog, is a DNA methylation inhibitor that acts by forming a covalent complex with DNA methyltransferases (DNMTs; Zhou et al.).
DIFFERENTIATION
· Induces cardiomyocyte differentiation from rat bone marrow mesenchymal stem cells (MSCs; Naeem et al.).
CANCER RESEARCH
· Reduces proliferation of the cancer cell lines TK6, Jurkat, KG-1, and HCT116 (Stresemann et al.).
· Inhibits cell proliferation in T24 bladder carcinoma cells (Ben-Kasus et al.).
· In combination with the histone deacetylase inhibitor SAHA, reduces cell proliferation and increases apoptosis in pancreatic cancer cell lines (Neureiter et al.).
· Inhibits cell proliferation and induces apoptosis in human acute myeloid leukemia cells in vitro (Scott et al.).
· Increases the proportion of cells with cancer stem cell properties in subpopulations of human cancer cells and liver cancer cell lines (Marquardt et al.).
CAS Number:3690-10-6
Alternative Names:NSC 309132
Chemical Formula:C₉H₁₂N₂O₅
Molecular Weight:228.2 g/mol
Purity:≥ 98%
Pathway:Epigenetic
Target:DNMT
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