Zoledronic Acid

Inhibitor of bone resorption; Inhibits farnesyl diphosphate (FPP) synthase

产品描述

• Zoledronic acid is a nitrogen-containing bisphosphonate that inhibits farnesyl diphosphate (FPP) synthase (IC₅₀ = 5 nM), thereby preventing protein prenylation and osteoclast-mediated bone resorption (Dunford et al.). In addition, it has a high affinity for hydroxyapatite (Ki = 3.5 μM) which allows it to bind directly to mineralized bone (Nancollas et al.). This product is supplied as the hydrate form of the molecule. CANCER RESEARCH · Inhibits proliferation, angiogenesis, and adhesion to bone, in several cancer cell lines (Li & Davis; Zekri et al.). · Inhibits breast and prostate carcinoma cell invasion in vitro (Boissier et al.; Li & Davis). · Induces apoptosis of osteoclastoma cells in vitro (Benford et al.).
• Components:

CAS Number:

165800-06-6

Alternative Names:

Zoledronate

Chemical Formula:

C₅H₁₀N₂O₇P₂ · H₂O

Molecular Weight:

290.1 g/mol

Purity:

≥ 95%

Target:

FPP Synthase

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