重组人TIM-3蛋白(Recombinant Human TIM-3 protein),GMP级
产品货号:GMP-TL731
产品描述(Description)
Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428, KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.
分子别名(Synonym)
HAVCR2、TIM3、TIMD3、FLJ14428、KIM3
表达宿主(Expression host)
HEK293 细胞
来源(Source)
Human
蛋白序列(Protein Sequence)
DNA 序列编码人 TIM3( NCBI Reference Sequence:NP_116171.3)表达带有 Fc 标签在 C 末端
分子量(Molecular Weight)
重组人 TIM-3 蛋白包含 412 个氨基酸,预测理论分子量为 49.5 kD
纯度(Purity)
≥95%采用 SDS-PAGE 凝胶和高效液相色谱分析
内毒素(Endotoxin)
<0.1EU/ug
生物活性 (Biological Activity)
固定人 TIM-3(Fc 标签)1ug/mL (100uL/孔) 能够结合抗人 TIM-3 的抗体的线性范围是 0.1-5ng/mL
组成(Component)
含有6%甘露醇的无菌PBS(PH 7.4)的冻干粉
稳定性(Stability)
冻干的样本的可以在4℃保存24个月,溶解后的液体可以于-20℃保存6-12个月,并且避免反复冻融
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