3000.00
重组小鼠CD4蛋白
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重组小鼠 CD4蛋白(Recombinant Murine CD4 Protein

产品货号:R-TL751


产品描述(Description)

T-cell surface glycoprotein CD4, is a single-pass type I membrane protein. CD4 contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.

同义词(Alternative Names)

L3T4 Protein, Mouse、 Ly-4 Protein, Mouse

蛋白序列(Protein Sequence)

DNA 序列编码小鼠 CD4(UniProtKB/Swiss-Prot: P06332)表达带有 His 标签在 C 末端

分子量(Molecular Weight)

重组小鼠 CD4 蛋白包含 381 个氨基酸,预测理论分子量为 42.9kD

表达宿主(Expression host)

 

HEK293细胞

纯度(Purity)

>90%,采用 SDS-PAGE 凝胶分析

内毒素(Endotoxin)

<1EU/μg

纯化方式( Purification Method )

层析纯化




性状(Character)

 

白色疏松体

使用说明(Instructions)

冻干制剂可在 2~8℃保存 24 个月。

如需分装,可用注射用水、生理盐水、培养基或 PBS 溶解,溶解后分装成小份,置于-20℃保存 期 6 个月,-80℃保存期 12 个月,稀释后浓度不低于 100μg/mL。避免反复冻融。



注意:所有产品仅用于非临床科研用途,不用于诊断、治疗、临床或其他用途

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市场价
3000.00
价格
3000.00
品牌
同立海源
型号
R-TL751
规格
100μg
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