2500.00
重组SARS-CoV-2棘突蛋白(S1亚基)
  • 产品详情
  • 产品参数
  • 产品评论

重组SARS-CoV-2棘突蛋白(S1亚基),GMP级

英文名称:Recombinant SARS-CoV-2 Spike Protein(S1 Subunit)

产品货号:GMP-TL761


产品描述(Description)

The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule. The spike is essential for both host specificity and viral infectivity. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that SARS-Cov-2   can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.

分子别名(Synonym)

2019-nCoV coronavirus spike Protein; 2019-nCoV cov spike Protein; ncov RBD Protein, 2019-nCoV; 2019-nCoV ncov s1 Protein; 2019-nCoV NCP-CoV s1 Protein;

表达宿主(Expression host)

 

HEK293细胞

蛋白序列(Protein Sequence)

DNA序列编码重组SARS-CoV-2 (2019-nCoV) S1蛋白表达带有His标签在C末端

分子量(Molecular Weight)

重组SARS-CoV-2 (2019-nCoV) S1蛋白包含698个氨基酸,预测的理论分子量为78.3kD

纯度(Purity)

>90% 采用SDS-PAGE凝胶分析

内毒素(Endotoxin)

≤0.01EU/ug(凝胶法)

图片(Images)

S1蛋白电泳图同立海源生物

稳定性(Stability)

1、冻干的样本可在4℃保存24个月,溶解后的液体可于-20℃保存6-12个月,并且避免反复冻融。

2、液体样本在-20~-80℃保存12个月,融化后需要进行分装保存于-20℃保存6-12个月,避免反复冻融。

组成(Component)

1.含有 6%甘露醇和 6%海藻糖的无菌 PBS(pH7.4)的冻干粉。

2.0.2 μM 无菌过滤的 PBS,pH 7.4 的液体。



注意:所有产品仅用于非临床科研用途,不用于诊断、治疗、临床或其他用途

重庆市寰宇安泰生物科技有限公司Chongqing Uante Biological Technology Co.,Ltd.】专注于生命科学科研试剂、耗材、仪器仪表等销售与科研技术服务。主营产品覆盖分子生物学、细胞生物学、免疫学、生物制药、诊断试剂研发、干细胞研究、美容抗衰等众多领域。代理或经销数十家知名品牌产品,如:OriGenStemCell、同立海源、CSTIGEBPALLSigmaThermo FisherLonzaBD等。面向全国销售,业务范围涉及:北京、天津、上海、重庆、河北石家庄、山西太原、内蒙古呼和浩特、辽宁沈阳、吉林长春、黑龙江哈尔滨、江苏南京、浙江杭州、安徽合肥、福建福州、江西南昌、山东济南、河南郑州、湖北武汉、河南长沙、广东广州、广西南宁、海南海口、四川成都、贵州贵阳、云南昆明、西藏拉萨、陕西西安、甘肃兰州、青海西宁、宁夏银川、乌鲁木齐等多省\\\自治州;将为广大科研用户在生命科学研究领域,提供高品质科研产品服务。公司秉承诚信为本、服务至上的管理理念,在未来的工作中,不断努力,奋发进取,力争成为您的科研物资战略合作优选伙伴!为生命科学领域的一线工作者提供最强有力的基础与支撑。

Uante,您的科研物资战略合作伙伴!

重庆市寰宇安泰生物科技有限公司

联系电话:023-67946738/17774916696

QQ:201719961   邮箱:info@uantebio.com


市场价
2500.00
价格
2500.00
品牌
同立海源
型号
GMP-TL761
规格
50μg
首页
客服