产品货号:GMP-TL764
产品描述(Description)
IFNs are a large family of proteins having antiviral, antiproliferative, and immunomodulatory effects, and are divided into two major classes, type I and type II, on the basis of differences in receptor binding and nucleotide sequence. Members of the type I interferon family, which includes IFN-α, IFN-β, and IFN- ω, signal through the IFNAR-1/IFNAR-2 receptor complex, and exert antiviral and antiproliferative activities. Human IFN-ω, was identified by three independent groups in 1985 and is structurally related to IFN-α and -β. Both human IFN-ω and IFN-α are produced by virally induced leukocytes and have similar antiviral activities on human cell lines, IFN-ω exhibits about 75% sequence homology with IFN-α, and contains two conserved disulfide bonds that are necessary for full biological activity. In addition, it was reported that IFN-ω could inhibit the growth of human tumors in vivo.
分子别名(Synonym)
Human IFN-omega 1 Protein; Human IFNW1 Protein; Human interferon omega-1 Protein;IFN alpha II-1, IFNW1
表达宿主(Expression host)
HEK293细胞
蛋白序列(Protein Sequence)
DNA 序列编码重组人 IFN-ω蛋白表达带有 His 标签在 C 末端
分子量(Molecular Weight)
重组人 IFN-ω蛋白包含 194 个氨基酸,预测的理论分子量为 22.5kd
纯度(Purity)
≥95%采用 SDS-PAGE 凝胶分析
内毒素(Endotoxin)
≤0.05EU/ug(凝胶法)
纯化方式(Purification Method)
层析纯化
保存温度(Storage Temperature)
2-8℃
性状(Character)
本品为白色疏松体
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