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重组人Transferrin(未脱铁)蛋白（Recombinant Human Holo-Transferrin Protein），GMP级

产品货号：GMP-TL757

产品描述（Description）

Transferrin is iron-binding blood plasma glycoproteins that control the level of free iron in biological fluids. This glycoprotein is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of Transferrin is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. It is a complex composed of alpha helices and beta sheets to form two domains (the first situated in the N-terminus and the second in the C-terminus). The N- and C- terminal sequences are represented by globular lobes and between the two lobes is an iron-binding site. The liver is the main source of manufacturing transferrin, but other sources such as the brain also produce this molecule . Transferrin is also associated with the innate immune system. Transferrin is found in the mucosa and binds iron, thus creating an environment low in free iron that impedes bacteria survival in a process called iron withholding. The level of transferrin decreases in inflammation. Transports iron ions from the hemolymph into the eggs during the vitellogenic stage. Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. The PH is reduced by hydrogen iron pumps. The lower pH causes transferrin to release its iron ions. The receptor is then transported through the endocytic cycle back to the cell surface, ready for another round of iron uptake. Each transferrin molecule has the ability to carry two iron ions in the ferric form

分子别名（Synonym）

Transferrin、TF、DKFZp781D0156、PRO1557、PRO2086

表达宿主（Expression host）

HEK293细胞

蛋白序列（Protein Sequence）

DNA 序列编码人 Transferrin（Q06AH7）表达带有 Fc 标签在 C 末端

分子量（Molecular Weight）

重组人 Transferrin 包含 713 个氨基酸，预测的理论分子量为 78.8kd

纯度（Purity）

≥95%采用 SDS-PAGE 凝胶和高效液相色谱分析

内毒素（Endotoxin）

≤0.01EU/ug（凝胶法）

生物活性（Biological Activity）

固定人转铁蛋白（His 标签）的浓度为 1ug/mL（100uL/孔）能够结合人转铁蛋白受体（Fc 标签）的的线性结合范围是 2-50 ng/mL

稳定性（Stability）

冻干的样本的可以在4℃保存24个月，溶解后的液体可以于-20℃保存6-12个月，并且避免反复冻融

组成（Component）

含有6%甘露醇的无菌PBS（PH 7.4）的冻干粉

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