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Sigma-Aldrich 94072 Phalloidin–Atto 565
产品编号 94072 | SIGMA
suitable for fluorescence, ≥80% (HPCE)
产品名称
General description
Atto 565 is a novel fluorescent label that belongs to the class of Rhodamine dyes. It shows a strong absorption, high fluorescence quantum yield, high thermal and photostability, and a very little triplet formation. Atto 565 consists of a mixture of two isomers with practically identical optical absorption and emission Phalloidin is a fungal toxin isolated from the poisonous mushroom Amanita phalloides. Its toxicity is attributed to the ability to bind F actin in liver and muscle cells. As a result of binding phalloidin, actin filaments become strongly stabilized. Phalloidin has been found to bind only to polymeric and oligomeric forms of actin, and not to monomeric actin. The dissociation constant of the actin-phalloidin complex has been determined to be on the order of 3 x 10-8. Phalloidin differs from amanitin in rapidity of action; at high dose levels, death of mice or rats occurs within 1 or 2 hours. Fluorescent conjugates of phalloidin are used to label actin filaments for histological applications. Some structural features of phalloidin are required for the binding to actin. However, the side chain of amino acid 7 (g-d-dihydroxyleucine) is accessible for chemical modifications without appreciable loss of affinity for actin.
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性质
Related Categories:Fluorescent Conjugates, Other Fluorescent Conjugates, 生化试剂, 荧光探针，标记，粒子和染色剂
assay:≥80% (HPCE)
mol wt :Mw 1394 g/mol
fluorescence:λex 563 nm; λem 592 nm in 0.1 M phosphate pH 7.0
suitability:suitable for fluorescence
storage temp.:−20°C
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