Purified anti-β-Amyloid, 17-24

￥ 21266.00

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Biolegend(Covance) 800703 Purified anti-β-Amyloid, 17-24 Antibody

产品编号 800703 | Biolegend(Covance)

产品描述

Clone:	4G8 (See other available formats)
Isotype:	Mouse IgG2b
Reactivity:	Human, Mouse
Formulation:	Phosphate-buffered solution (no preservatives or carrier proteins).
Preparation:	The antibody was purified by affinity chromatography.
Concentration:	1 mg/ml
Storage & Handling:	The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
Application:	ELISA, WB, IHC, IP
Recommended Usage:	Each lot of this antibody is quality control tested by ELISA assay.The optimal working dilution should be determined for each specific assay condition. • WB: 1:100 - 1:1,000*• IHC: 1:500 - 1:1,000Tissue: Formalin-fixed human and animal paraffin-embedded brain sections, frozen tissue sectionsPre-treatment: Formic acid (70%) for 10-30 minutes at room temperature• IP: 1:250 - 1:500
ApplicationNotes:	This antibody is effective in immunoblotting (WB), immunohistochemistry (IHC), immunopurification (IP), and ELISA.*Expected MW: APP= 100 kD; Beta Amyloid = 4 kDThis antibody is reactive to amino acid residues 17-24 of β amyloid. THe epitope lies within amino acids 18-22 of β amyloid (VFFAE). β amyloid forms are deposited in the CNS of patients with Alzheimer's disease and Down's syndrome. 4G8 β amyloid antibody reacts to the abnormally processed isoforms, as well as precursor forms.
ApplicationReferences:	1. Thakker DR, et al. Intracerebroventricular amyloid-beta antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice. Proc Natl Acad Sci USA Feb 25, 2009.2. Kimura N, et al. Age-related changes of intracellular Abeta in cynomolgus monkey brains. Neuropath Appl Neurobiol 31(2):170-80, 2005.3. Klyubin I, et al. Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. Nat Med 11(5):556-61, 2005.4. Iijima K, et al. Dissecting pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's disease. PNAS 101(17):6623-6628, 2004.5. Li M, et al. Macrophage colony stimulatory factor and interferon-gamma trigger distinct mechanisms for augmentation of beta-amyloid-induced microgliamediated neurotoxicity. J Neurochem 91:623-33, 2004.6. Poduloso JF, et al. Design and chemical synthesis of a magneticresonance contrast agent with enhanced in vitro binding, high blood-brain barrier permeability, and in vivo targeting to Alzheimer's disease amyloid plaques. Biochem 43:6064-6075, 2004.7. Venezia V, et al. Apoptotic cell death influences the signaling activityof the amyloid precursor protein through SchA and Grb2 adaptor proteins inneuroblastoma SH-SY5Y cells. J Neurochem 90:1359-1370, 2004.8. Kim KS, et al. Production and characterization of monoclonal antibodies reactive to synthetic cerebrovascular amyloid peptide.Neurosci Res Comm 2:121-130, 1988.9. Kim KS, et al. Neurosci Res Comm 7:113, 1988. 10. Lablans A, et al. 2014. J. Neurosci. 34:13629. (WB, IHC)PubMed 11. Lutzenberger M, et al. 2015. PLOS ONE. 10: 0134228.PubMed12. Lian H, et al. 2016. J. Neurosci.. 36: 577 - 589. PubMed
	Publication Library
RRID:	AB_2564633 (BioLegend Cat. No. 800701)AB_2564634 (BioLegend Cat. No. 800702)AB_662812 (BioLegend Cat. No. 800703)

公司简介

Covance主要业务是研发和生产各种抗体，涉及领域包括：神经生物学、免疫病理学、细胞生物学、表位抗体和免疫组化等方面的科研试剂。特色产品是免疫组化的体外诊断试剂。美国 BioLegend 公司于圣地亚哥时间2014年8月29日收购了位于马萨诸塞州戴德姆的科文斯（Covance）旗下的科文斯抗体服务公司（Covance Antibody Services Inc.）。科文斯抗体服务公司主要业务是研发和生产各种抗体，涉及领域包括:神经生物学、免疫病理学、细胞生物学、表位抗体和免疫组化等方面的科研试剂。这些用于免疫组化的体外诊断试剂（IVD）对于 BioLegend 公司目前的科研试剂产品线是一个很好的补充和扩展。科文斯抗体的客户将享有与 BioLegend 当前客户同样的优质服务和高性价比的产品。

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市场价

￥21266.00

价格

￥21266.00

品牌

Biolegend(Covance)

型号

800703