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Biolegend(Covance) 802801 Purified anti-APP C-Terminal Fragment Antibody
产品编号 802801| Biolegend(Covance)
产品描述
Clone: | C1/6.1 (See other available formats) |
Isotype: | Mouse IgG1 |
Reactivity: | Human, Mouse, Rat, Rodent |
Immunogen: | This antibody was raised against the conserved carboxyl-terminal 20 residues of APP (residues 676-695 of APP695). |
Formulation: | Phosphate-buffered solution (no preservatives or carrier proteins). |
Preparation: | The antibody was purified by affinity chromatography. |
Concentration: | 1 mg/ml |
Storage & Handling: | The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody. |
Application: | ELISA, WB, ICC, IP |
Recommended Usage: | Each lot of this antibody is quality control tested by ELISA assay.The optimal working dilution should be determined for each specific assay condition.• WB: 1:500 - 1:1,0000*• ICC: 1:500 - 1:1,0000• IP: 1:100 - 1:200• ELISA: 1:100 - 1:200 |
ApplicationNotes: | This antibody is effective in immunoblotting (WB), immunocytochemistry (ICC), immunoprecipitation (IP), and ELISA.*Expected MW: APP= 100 kD; alphaCTF & betaCTF= 10 kD |
ApplicationReferences: | 1. Lee M, Lin S, Chang J, Schultz L. TGF-β induces TIAF1 self-aggregation via type II receptor-independent signaling that leads to generation of amyloid β plaques in Alzheimer's disease. Cell Death Dis.: 1(12): Dec 2010. 2. Jiang Y, Mullaney KA, Peterhoff CM, Che S, Schmidt SD, Boyer-Boiteau A, Ginsberg SD, Cataldo AM, Mathews PM, Nixon RA. Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition. Proc Natl Acad Sci USA 107(4):1630-5, 2010. [WB, ICC]PubMed 3. Laudon H, Karlström H, Mathews PM, Farmery MR, Gandy SE, Lundkvist J, Lendahl U, Nslund J. Functional domains in presenilin 1: the Tyr-288 residue controls gamma-secretase activity and endoproteolysis. J Biol Chem 279(23):23925-32, 2004. [IP] 4. Grbovic OM, Mathews PM, Jiang Y, Schmidt SD, Dinakar R, Summers-Terio NB, Ceresa BP, Nixon RA, Cataldo AM. Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production. J Biol Chem 278(33):31261-8, 2003. [IP] 5. Mathews PM, Jiang Y, Schmidt SD, Grbovic OM, Mercken M, Nixon RA. Calpain activity regulates the cell surface distribution of amyloid precursor protein. Inhibition of calpains enhances endosomal generation of beta-cleaved C-terminal APP fragments.J Biol Chem 277(39):36415-24, 2002. [WB] 6. Corbett GT, et al. 2015. PNAS. |
Publication Library | |
RRID: | AB_2564648 (BioLegend Cat. No. 802801)AB_2564647 (BioLegend Cat. No. 802802) |
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公司简介
Covance主要业务是研发和生产各种抗体，涉及领域包括：神经生物学、免疫病理学、细胞生物学、表位抗体和免疫组化等方面的科研试剂。特色产品是免疫组化的体外诊断试剂。美国 BioLegend 公司于圣地亚哥时间2014年8月29日收购了位于马萨诸塞州戴德姆的科文斯（Covance）旗下的科文斯抗体服务公司（Covance Antibody Services Inc.）。科文斯抗体服务公司主要业务是研发和生产各种抗体，涉及领域包括:神经生物学、免疫病理学、细胞生物学、表位抗体和免疫组化等方面的科研试剂。这些用于免疫组化的体外诊断试剂（IVD）对于 BioLegend 公司目前的科研试剂产品线是一个很好的补充和扩展。科文斯抗体的客户将享有与 BioLegend 当前客户同样的优质服务和高性价比的产品。
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