Purified anti-β-Amyloid, 1-16

￥ 6608.00

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Biolegend(Covance) 803001 Purified anti-β-Amyloid, 1-16 Antibody

产品编号 803001| Biolegend(Covance)

产品描述

Clone:	6E10 (See other available formats)
Isotype:	Mouse IgG1
Reactivity:	Human
Formulation:	Phosphate-buffered solution (no preservatives or carrier proteins).
Preparation:	The antibody was purified by affinity chromatography.
Concentration:	1 mg/ml
Storage & Handling:	The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
Application:	ELISA, WB, IHC, IP
Recommended Usage:	Each lot of this antibody is quality control tested byELISA assay.The optimal working dilution should be determined for each specific assay condition. • WB: 1:1,000 - 1:2,000*• IHC: 1:100 - 1:1,000Tissue: Formalin-fixed human paraffin-embedded brain sections, frozen brain sectionsPre-treatment: Formic acid (70%) for 10-30 minutes at room temperature
ApplicationNotes:	This antibody is effective in immunoblotting (WB), immunohistochemistry (IHC), immunoprecipitation (IP), and ELISA.*Expected MW: APP = ~100 kD, sAPPalpha = ~100 kD, Beta Amyloid = 4 kDThis antibody is reactive to amino acid residue 1-16 of beta amyloid. The epitope lies within amino acids 3-8 of beta amyloid (EFRHDS). Beta amyloid forms are deposited in the CNS of patients with Alzheimer's disease and Down's syndrome. BioLegend's beta amyloid antibody clone 6E10 reacts to the abnormally processed isoforms, as well as precursor forms. This antibody is exclusively provided by BioLegend.
ApplicationReferences:	1. Thakker DR, et al. Intracerebroventricular amyloid-beta antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice.Proc Natl Acad Sci USA Feb 25, 2009.2. Klyubin I, et al. Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. Nat Med 11(5):556-61, 2005.3. Oddo S, et al. Chronic nicotine administration exacerbates taupathology in a transgenic model of Alzheimer's disease. PNAS 102(8):3046-51, 2005.4. Fratta P, et al. Mutant ubiquitin UBB+1 is accumulated in sporadicinclusion-body myositis muscle fibers.Neurology 63:1114-1117, 2004.5. Funamoto S, et al. Truncated carboxyl-terminal fragments of beta-Amyloid precursor protein are processed to Amyloid beta-proteins 40 and 42. Biochem 43:13523-13540, 2004.6. Herzig M, et al. Abeta is targeted to the vasculature in a mouse model ofheredity cerebral hemorrhage with amyloidosis. Nat. Neuro. 7(9):954-959, 2004.7. Kim KS, et al. Production and characterization of monoclonal antibodies reactive to synthetic cerebrovascular amyloid peptide. Neurosci. Res. Comm. 2:121-130, 1988.8. Kim KS, et al. Neurosci. Res. Comm. 7:113, 1988.9. Sandoval-Hernández A, et al. 2015. PLOS ONE. 10: 0145467. PubMed10. Kumar R, et al. 2016. Brain. 139: 174 - 192. PubMed11. Miyamoto T, et al. 2016. J. Biol. Chem.. 291: 1719 - 1734. PubMed12. Baruch K, et al. 2016. Nat Med. 22:135-137.PubMed
	Publication Library
RRID:	AB_2564653 (BioLegend Cat. No. 803001)AB_2564654 (BioLegend Cat. No. 803002)AB_2564652 (BioLegend Cat. No. 803003)

公司简介

Covance主要业务是研发和生产各种抗体，涉及领域包括：神经生物学、免疫病理学、细胞生物学、表位抗体和免疫组化等方面的科研试剂。特色产品是免疫组化的体外诊断试剂。美国 BioLegend 公司于圣地亚哥时间2014年8月29日收购了位于马萨诸塞州戴德姆的科文斯（Covance）旗下的科文斯抗体服务公司（Covance Antibody Services Inc.）。科文斯抗体服务公司主要业务是研发和生产各种抗体，涉及领域包括:神经生物学、免疫病理学、细胞生物学、表位抗体和免疫组化等方面的科研试剂。这些用于免疫组化的体外诊断试剂（IVD）对于 BioLegend 公司目前的科研试剂产品线是一个很好的补充和扩展。科文斯抗体的客户将享有与 BioLegend 当前客户同样的优质服务和高性价比的产品。

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市场价

￥6608.00

价格

￥6608.00

品牌

Biolegend(Covance)

型号

803001