Purified anti-Tubulin β-3 (TUBB3)

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Biolegend 802001 Purified anti-Tubulin β-3 (TUBB3) Antibody

产品编号 802001| biolegend

产品描述

Product Details
Clone:	Poly18020 (See other available formats)
Isotype:	Rabbit Polyclonal
Reactivity:	Mammalian
Immunogen:	This antibody was generated against the same epitope as recognized by TUJ1 and was subsequently purified on a peptide affinity column.
Formulation:	Phosphate-buffered solution + 0.03% Thimerosal + 50% Glycerol.
Preparation:	The antibody was purified by affinity chromatography.
Concentration:	1 mg/ml
Storage & Handling:	Store between 2°C and 8°C.
Application:	IHC, WB, IF, ICC
Recommended Usage:	Each lot of this antibody is quality control tested by immunohistochemical staining.
	The optimal working dilution should be determined for each specific assay condition.
	• WB: 1:5,000*
	• ICC: 1:1,000-1:2,500
	• IHC: 1:5,000-10,000
	Tissue Sections: Formalin-fixed, paraffin-embedded tissues & frozen sections
	Pretreatment: For optimal staining, the sections should be pretreated with an antigen unmasking solution such as citrate buffer retrieval solution (Cat. No. 928501, 928601).
	Incubation: 60 minutes at room temperature
Application	This antibody is effective in immunoblotting (WB), immunocytochemistry (ICC), and immunohistochemistry (IHC).
Notes:
	*Predicted MW = 50 kD
	This antibody is well characterized and highly reactive to neuron specific Class III β-Tubulin (βIII), but does not identify β-tubulin found in glial cells.
Application	1. Feuer R, Pagarigan RR, Harkins S, Liu F, Hunziker IP, Whitton JL. Coxsackievirus targets proliferating neuronal progenitor cells in the neonatal CNS. J. Neurosci. 25(9):2434-44, 2005.
References:	2. Mozzetti S, Ferlini C, Concolino P, Filippetti F, Raspaglio G, Prislei S, Gallo D, Martinelli E, Ranelletti FO, Ferrandina G, Scambia G. Class III beta-tubulin overexpression is a prominent mechanism of paclitaxel resistance in ovarian cancer patients. Clin. Cancer Res. 11(1):298-305, 2005.
	3. Feuer R, Mena I, Pagarigan RR, Harkins S, Hassett DE, Whitton JL. Coxsackievirus B3 and the neonatal CNS: the roles of stem cells, developing neurons, and apoptosis in infection, viral dissemination, and disease. Am. J. Pathol. 163(4):1379-93, 2003.
	4. Zhang XM, Yang XJ. Regulation of retinal ganglion cell production by Sonic hedgehog. Development 128(6):943-957, 2001.
	5. Ma M, et al. 2012. Neurobiol Dis. 56:34. (WB) PubMed
	6. Tseung G, et al. 2011. J. Virol. 85:5718. (IF) PubMed
	7. Shimada IS, et al. 2012. J Neurosci. 32:7926. (IHC)PubMed
	8. Flores-Otero J, et al. 2007. J. Neurosci. 27:14023. (IF)PubMed
	9. Macpherson P, et al. 2015. Development. 142: 4038 - 4048. PubMed
	10. Yau K, et al. 2016. J. Neurosci.. 36: 1071 - 1085.PubMed
	11. Chow A, Morshead C 2016. Stem Cell Res. 16:79-87.PubMed
	12. Cui Q, et al. 2016. Nat Commun. 7:10637. PubMed
	Publication Library
RRID:	AB_2564645 (BioLegend Cat. No. 802001)
Antigen Details
Description:	Tubulin is the main component of microtubules. In adults, tubulin beta 3 (TUBB3) is primarily expressed in neurons and is commonly used as a neuronal marker. It plays an important role in neuronal cell proliferation and differentiation. Mutations in this gene cause congenital fibrosis of the type 3 extraocular muscles. Tubulin beta 3 (TUBB3) is also found in a wide range of tumors. Studies indicate that it is a predictive and prognostic marker in various tumors.
Other Names:	CDCBM, CDCBM1, CFEOM3, CFEOM3A, FEOM3, TUBB4, Tubulin beta-3 chain, tubulin beta-III, TUBB3, tubulin beta-4 chain, class III beta-tubulin
GeneID:	10381
UniProt:	View information about Tubulin beta-3 (TUBB3) on UniProt.org
Keywords:	Purified anti-Tubulin β-3 (TUBB3), Poly18020, Purified, CDCBM, CDCBM1, CFEOM3, CFEOM3A, FEOM3, TUBB4, Tubulin beta-3 chain, tubulin beta-III, TUBB3, tubulin beta-4 chain, class III beta-tubulin, Mammalian, Immunohistochemistry, Western Blotting, Immunofluorescence microscopy, Immunocytochemistry, Immunology, Antibodies

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￥5166.00

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￥5166.00

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Biolegend(Covance)

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