Purified anti-β-Amyloid, 1-16

￥ 6608.00

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Biolegend 803001 Purified anti-β-Amyloid, 1-16 Antibody

产品编号 803001| biolegend

产品描述

Product Details
Clone:	6E10 (See other available formats)
Isotype:	Mouse IgG1
Reactivity:	Human
Formulation:	Phosphate-buffered solution (no preservatives or carrier proteins).
Preparation:	The antibody was purified by affinity chromatography.
Concentration:	1 mg/ml
Storage & Handling:	The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
Application:	ELISA, WB, IHC, IP
Recommended Usage:	Each lot of this antibody is quality control tested byELISA assay.
	The optimal working dilution should be determined for each specific assay condition.
	• WB: 1:1,000 - 1:2,000*
	• IHC: 1:100 - 1:1,000
	Tissue: Formalin-fixed human paraffin-embedded brain sections, frozen brain sections
	Pre-treatment: Formic acid (70%) for 10-30 minutes at room temperature
Application	This antibody is effective in immunoblotting (WB), immunohistochemistry (IHC), immunoprecipitation (IP), and ELISA.
Notes:
	*Expected MW: APP = ~100 kD, sAPPalpha = ~100 kD, Beta Amyloid = 4 kD
	This antibody is reactive to amino acid residue 1-16 of beta amyloid. The epitope lies within amino acids 3-8 of beta amyloid (EFRHDS). Beta amyloid forms are deposited in the CNS of patients with Alzheimer's disease and Down's syndrome. BioLegend's beta amyloid antibody clone 6E10 reacts to the abnormally processed isoforms, as well as precursor forms.
	This antibody is exclusively provided by BioLegend.
Application	1. Thakker DR, et al. Intracerebroventricular amyloid-beta antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice.Proc Natl Acad Sci USA Feb 25, 2009.
References:	2. Klyubin I, et al. Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. Nat Med 11(5):556-61, 2005.
	3. Oddo S, et al. Chronic nicotine administration exacerbates taupathology in a transgenic model of Alzheimer's disease. PNAS 102(8):3046-51, 2005.
	4. Fratta P, et al. Mutant ubiquitin UBB+1 is accumulated in sporadicinclusion-body myositis muscle fibers.Neurology 63:1114-1117, 2004.
	5. Funamoto S, et al. Truncated carboxyl-terminal fragments of beta-Amyloid precursor protein are processed to Amyloid beta-proteins 40 and 42. Biochem 43:13523-13540, 2004.
	6. Herzig M, et al. Abeta is targeted to the vasculature in a mouse model ofheredity cerebral hemorrhage with amyloidosis. Nat. Neuro. 7(9):954-959, 2004.
	7. Kim KS, et al. Production and characterization of monoclonal antibodies reactive to synthetic cerebrovascular amyloid peptide. Neurosci. Res. Comm. 2:121-130, 1988.
	8. Kim KS, et al. Neurosci. Res. Comm. 7:113, 1988.
	9. Sandoval-Hernández A, et al. 2015. PLOS ONE. 10: 0145467. PubMed
	10. Kumar R, et al. 2016. Brain. 139: 174 - 192. PubMed
	11. Miyamoto T, et al. 2016. J. Biol. Chem.. 291: 1719 - 1734. PubMed
	12. Baruch K, et al. 2016. Nat Med. 22:135-137.PubMed
	Publication Library
RRID:	AB_2564653 (BioLegend Cat. No. 803001)
	AB_2564654 (BioLegend Cat. No. 803002)
	AB_2564652 (BioLegend Cat. No. 803003)
Antigen Details
Description:	Amyloid beta (Aβ or Amyloid beta) denotes peptides of 36-43 amino acids in length that are crucially involved in Alzheimer's disease as the main component of the amyloid plaques found in the brains of Alzheimer patients. The peptides result from the amyloid precursor protein (APP), which is cut by certain enzymes to yield Aβ. Aβ molecules can aggregate to form oligomers (known as "seeds") which are believed to be able to induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection. The seeds or the resulting amyloid plaques are toxic to nerve cells. The other protein implicated in Alzheimer's disease, tau protein, also forms such prion-like misfolded oligomers, and there is some evidence that misfolded Aβ can induce tau to misfold.
Other Names:	AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, Amyloid beta A4 protein, preA4, protease nexin-II, peptidase nexin-II, beta-amyloid peptide, alzheimer disease amyloid protein, cerebral vascular amyloid peptide, APP, Amyloid Precursor Protein<sig-39320-200,sig-39320-500,sig-39320-1000 style="font-family: Arial, Helvetica, sans-serif; font-size: 14px; color: rgb(51, 51, 51);"><932002><932005><932010>
GeneID:	351
UniProt:	View information about beta-Amyloid, 1-16 on UniProt.org
Keywords:	Purified anti-β-Amyloid, 1-16 , 6E10, Purified, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, Amyloid beta A4 protein, preA4, protease nexin-II, peptidase nexin-II, beta-amyloid peptide, alzheimer disease amyloid protein, cerebral vascular amyloid peptide, APP, Amyloid Precursor Protein<sig-39320-200,sig-39320-500,sig-39320-1000 style="font-family: Arial, Helvetica, sans-serif; font-size: 14px; color: rgb(51, 51, 51);"><932002><932005><932010>, Human, ELISA, Western Blotting, Immunohistochemistry, Immunoprecipitation, Immunology, Antibodies

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￥6608.00

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￥6608.00

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Biolegend(Covance)

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