Research Diets  D12079B Western Diets

产品编号 D12079B |Research Diets

Western Diets

产品描述

Western Diets

Grain-based Chow Diets

• In the past, Western-type diets have been made by adding high levels of fat and cholesterol to grain-based chow diets. The addition of ingredients to chows can dilute other nutrients (i.e. vitamins, minerals, protein, etc) and non-nutrients (i.e. phytoestrogens), so their use in research has been criticized (1).

OpenSource Purified Diets

• In order to avoid this issue, purified ingredient diet formulas which are open to the public (i.e. AIN-76A) can be easily revised to intentionally alter the phenotype by adding in fat calories (i.e. dairy butter, hydrogenated coconut oil) in place of purified carbohydrate calories only (i.e. sucrose, corn starch). This method of modification maintains nutrient to calorie ratios, which is important as animals typically eat for calories, not weight of food. Furthermore, casein-based purified diets contain nophytoestrogens (or other phytochemicals) unlike typical grain-based chows which can have highly variable levels (2). Since the presence of phytoestrogen containing sources (i.e. soy protein and isolated isoflavones) has been found to influence atherosclerosis and lipoprotein metabolism in various rodent models (3-9), the use of purified Western-type diets provides a clean ‘reagent’ for inducing this disease. That being said, not all rodent models respond the same to a given Western-type purified diet due to genetic differences.

References:

• 1. Cybulsky,MI, Lichtman,AH, Haijra,L, Iiyama,K. Leukocyte adhesion molecules in atherogenesis: Clinica Chimica Acta 286:207-218, 19992. Thigpen,JE, Setchell,KD, Ahlmark,KB, Locklear,J, Spahr,T, Caviness,GF, Goelz,MF, Haseman,JK, Newbold,RR, Forsythe,DB: Phytoestrogen content of purified, open- and closed-formula laboratory animal diets. Lab Anim Sci. 49:530-536, 19993. Brown,NM, Setchell,KD: Animal models impacted by phytoestrogens in commercial chow: implications for pathways influenced by hormones. Lab Invest 81:735-747, 20014. Mezei,O, Banz,WJ, Steger,RW, Peluso,MR, Winters,TA, Shay,N: Soy isoflavones exert antidiabetic and hypolipidemic effects through the PPAR pathways in obese Zucker rats and murine RAW 264.7 cells. J Nutr. 133:1238-1243, 20035. Kirk E, Sutherland P, Wang S, Chait A, LeBoeuf R: Dietary isoflavones reduce plasma cholesterol and atherosclerosis in C57BL/6 mice but not LDL receptor-deficient mice. J Nutr 128:954-959, 19986.Torvar-Palacio C, Potter SM, Hafermann JC, Shay NF: Intake of soy protein and soy protein extracts influences lipid metabolism and hepatic gene expression in gerbils. J Nutr 128:839-42, 19987.Blair,RM, Appt,SE, Bennetau-Pelissero,C, Clarkson,TB, Anthony,MS, Lamothe,V, Potter,SM: Dietary soy and soy isoflavones have gender-specific effects on plasma lipids in Golden Syrian F1B Hybrid Hamsters. J Nutr 1323585-3591, 20028.Ascencio,C, Torres,N, Isoard-Acosta, F, Gomez-Perez,FJ, Hernandez-Pando,R, Tovar,AR: Soy protein affects serum insulin and hepatic SREBP-1 mRNA and reduces fatty liver in rats. J Nutr 134:522-529, 20049. Adams,MR, Golden,DL, Anthony,MS, Register,RC, and Koudy Williams,J: The inhibibory effect of soy protein isolate on atherosclerosis in mice does not require the presence of LDL receptors or alteration of plasma lipoproteins. J Nutr 132:43-49, 2002

产品详情

Stock Diets

• A number of OpenSource diet formulations have been widely published and have become the standards for many diet-induced disease models. These diets are kept in stock and ready for next day shipment. Our stock diets provide a clean, open formula background in which to make modifications. See our custom diets page for more information on custom formulations.
• The following is a list of our stock purified diets:




Formulation	Description	In-Stock	IrradiatedIn-Stock
D12450B	DIO (LFD) 10 kcal% fat 35% Sucrose	Yes	Yes	References
D12450J	DIO (LFD) 10 kcal% fat D12492 Match 17% Sucrose	Yes	Inquire
D12451	DIO (HFD) 45 kcal% fat	Yes	Yes	References
D12492	DIO (VHFD) 60 kcal% fat	Yes	Yes	References
D10001	AIN-76A	Yes	Inquire	References
D10012G	AIN-93G	Yes	Inquire	References
D10012M	AIN-93M	Yes	Inquire	References
D12266B	Purified match to C11024 Condensed Milk Diet	Inquire	Inquire	References
D12489B	Low-fat control to D12266B	Inquire	Inquire	References
D12079B	RD Western Diet	Yes	Inquire	References
D12330	58 kcal% fat w/corn starch	Inquire	Inquire	References
D12328	Control: 11 kcal% fat w/corn starch	Inquire	Inquire	References
D12331	58 kcal% fat w/sucrose	Yes	Yes	References
D12329	Control: 11 kcal% fat w/sucrose	Inquire	Inquire	References
D12108C	40 kcal% fat (mostly cocoa butter) and 1.25% cholesterol	Yes	Inquire	References




• All our stock diets can be irradiated. To order irradiated diets add the letter "i" to the end of the diet number. For example D12492i.
• These are just a few of the over 20,000 original diet formulas available to you. Contact one of ournutrition scientists for assistance in finding the formula for you specific study needs.

A Word of Caution

• Don’t be misled by diet manufacturers who claim to offer the same OpenSource diet formulas as Research Diets, Inc. Though it is true that all our formulas are open, there may be differences in the sources of ingredients or the vitamin and mineral mixes used to produce the diet. There is only one sure way to repeat research based on the "Original" OpenSource Diet formula—go to the source of that formula. There is only one place to get OpenSource Diets and that’s at Research Diets, Inc.

公司简介

美国research diets公司是一家专业生产实验室动物饲料的大型公司，包括脂肪热能的颗粒饲料及各种维生素缺乏饲料的专业供应商，Research Diets是生产动物实验用高脂肪饲料的先驱，可配制高达 60 kcal% 的高脂肪饲料，成份內含各式脂肪及碳水化合物，Research Diets长期陪伴实验室科研人员，以配制研究需要的饲料配方，可用于诱发肥胖病及糖尿病的特殊饲料如D12450B、D12451及 D12492, Research Diets拥有配方饲料种类超过15000种，常规高端饲料10多种如AIN-76A Western饲料等’

Uante,您的科研物资战略合作伙伴！

重庆市寰宇安泰生物科技有限公司

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