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InvivoGen ant-ph-10p Phleomycin (powder)
Phleomycin
Phleomycin is a glycopeptide antibiotic of the bleomycin family, isolated from a mutant strain of Streptomyces verticillus. It binds and intercalates DNA thus destroying the integrity of the double helix. Phleomycin is active against most bacteria, filamentous fungi, yeast, plant and animal cells. Use of phleomycin is recommended for cells poorly sensitive to Zeocin™, i.e. filamentous fungi and some yeasts. Phleomycin resistance is conferred by the Sh ble gene from Streptoalloteichus hindustanus which encodes a protein that binds to phleomycin, inhibiting its DNA cleavage activity.
Typically, phleomycin is used at a concentration of 10 µg/ml for yeasts and 25-150 µg/ml for filamentous fungi.
Specifications Product concentration: 20 mg/ml in solutionCAS number: 11006-33-0
Quality Control: Each lot is thoroughly tested to ensure the absence of lot-to-lot variation.Endotoxin level: < 1 EU/mgPhysicochemical characterization: HPLC, pH, appearanceCell culture tested: potency validated in phleomycin-sensitive and phleomycin-resistant bacterial, fungal and mammalian cellsNon-cytotoxicity of trace contaminants: absence of long-term effects confirmed in phleomycin-resistant cells
ContentsPhleomycin is supplied as a sterile filtered blue solution at 20 mg/ml in HEPES buffer. This product is available in three pack sizes:- ant-ph-1: 5 x 1 ml (100 mg)- ant-ph-5: 25 x 1 ml (500 mg)- ant-ph-5b: 1 x 25 ml (500 mg)
Phleomycin is also supplied as a blue powder:- ant-ph-2p: 250 mg - ant-zn-5p: 2 x 250 mg (500 mg) - ant-zn-10p: 1 gPhleomycin is shipped at room temperature. Upon receipt it should be stored at 4°C or -20°C.
产品描述
Selective Antibiotics
InvivoGen is a leader in the production of selection antibiotics. Our state-of-the-art facilities allow us to produce large quantities of high quality, endotoxin-free antibiotics with purity levels exceeding 95%. As we manufacture our products, we are able to offer the best prices on the market.
Ready-to-use Cell Culture Tested Solutions - No weighing needed - Our antibiotics are available in solution filtered to sterility for customer convenience and validated for cell culture usage.
An Excellent Choice of Antibiotics for Selection in Both Mammalian cells and E. coli - Matches up to the antibiotic resistance genes carried by InvivoGen plasmids, built for selection in both mammalian and bacteria cells.
窗体顶端 窗体底端 | Selective antibiotic for the bsr or BSD genes | 1 g 100 mg (10 x 1 ml) 500 mg (50 ml bottle) 500 mg (50 x 1 ml) |
窗体顶端 窗体底端 | Selective antibiotic for the Sh ble gene | 1 g (powder) 1g (10 x 1 ml) 5g (50 x 1 ml) 5 g (50 ml bottle) 5 g (powder) |
窗体顶端 窗体底端 | Selective antibiotic for the pac gene | 500 mg (50 x 1 ml) 500 mg (1 x 50 ml) 100 mg (10 x 1 ml) |
窗体顶端 窗体底端 | Selective antibiotic for the neo gene | 1 g (10 x 1ml) 5 g (1 x 50 ml) |
窗体顶端 窗体底端 | Selective antibiotic for the hph gene - Hygromycin B High purity | 1 g (10 x 1 ml) 5 g (1 x 50 ml) |
窗体顶端 窗体底端 | Selective antibiotic for the Sh ble gene | 1 g 100 mg (5 x 1 ml) 500 mg (25 x 1 ml) 500 mg (25 ml) 250 mg 500 mg |
其他产品线
1-Cell Culture and Transfection Reagents:
Powerful reagents to prevent microbial contamination in cell culture, plus a wide variety of selection antibiotics and reporter (secreted embryonic alkaline phosphatase (SEAP) or Lucia luciferase) detection reagents, and a transfection reagent;
2-Mammalian Expression Vectors:
A broad array of cloning vectors, that include plasmidic and lentiviral vectors, and CpG-free plasmids, a choice of inducible reporter plasmids, plus an expanding library of human and murine genes, and a wide variety of cellular promoters;
3-Reporter Cells:
A growing collection of functionally validated and mycoplasma-free human and murine cell lines, such as HEK293-, Jurkat-, RAW 264.7- and THP-1-derived cells, that report on one or more pattern recognition receptor (PRR), cytokine, or transcription factor activities using SEAP and/or Lucia luciferase, plus a recently launched line of knockout cells that lack major innate immune sensors or signaling proteins;
4-PRR Ligands:
An expanding collection of agonists and control ligands for all the major PRRs, such as Toll-like receptors (TLRs), NOD-like receptors (NLRs) and cytosolic DNA sensors (CDSs), including ligands of natural and synthetic origin, all screened and validated in-house;
5-Inhibitors:
A wide selection of functionally validated compounds to directly or indirectly block the principal immune (TLR, NLR, CDS) pathways and related signaling pathways;
6-Antibodies and Recombinant Proteins:
A large variety of biologically validated monoclonal and polyclonal antibodies against major human and murine innate immune targets, as well as isotype families of clinically relevant antibodies, plus a selection of recombinant cytokines;
7-Vaccination:
Pre-clinical grade vaccine adjuvants that comprise alum, emulsions, such as CFA and saponin, and PRR ligands, plus various ovalbumin-derived products.
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