Normocin™ - Antimicrobial Reagent
Prevention Against Mycoplasma, Bacteria and Fungi
Normocin™ is used as a "routine addition" to cell culture media to prevent mycoplasma, bacterial and fungal contaminations in small or large scale animal cell cultures. Normocin™ can be used in combination with Pen-Strep solutions to broaden the anti-bacterial spectrum.
Normocin™ is an innovative formulation developed by InvivoGen of three antibiotics active against mycoplasmas, bacteria and fungi. Normocin™ contains two compounds that act on mycoplasmas and both Gram+ and Gram - bacteria by blocking DNA and protein synthesis. The third compound eradicates yeasts and fungi by disrupting ionic exchange through the cell membrane.
Specifications
Product concentration: 50 mg/ml
Active concentration not toxic for treated cell lines: 100 μg/ml
1 ml Normocin™ is enough to treat 500 ml medium
Shipped at room temperature
Contents
Normocin™ is provided as a cell culture tested, sterile filtered red solution at a concentration of 50 mg/ml in different formats:
- 10 x 1 ml vial (500 mg)
- 1 x 20 ml bottle (1 g)
Antimicrobial Agents
Microbial contamination of cell culture is a major concern for cell biologists in research laboratories as well as in biotechnological industries. The use of infected cell lines can lead to unreliable experiments and unsafe biologicals and biopharmaceutical drugs, and is costly in time and materials.
Microbial contaminants, whether mycoplasmas, bacteria or fungi, can now be eliminated from cell cultures by using the right antibiotic treatment.
Antimicrobial Agents
PlasmoTest™, Plasmocin™ and Plasmocure™ | |
For preventing contamination of cell cultures by mycoplasma, bacteria or fungi | |
Broad-spectrum Antibacterial Agent for the Treatment of Contaminated Cell Cultures | |
Antimicrobial agent for prevention and elimination of Fungi | |
Antimicrobial agent for primary cells |
1-Cell Culture and Transfection Reagents:
Powerful reagents to prevent microbial contamination in cell culture, plus a wide variety of selection antibiotics and reporter (secreted embryonic alkaline phosphatase (SEAP) or Lucia luciferase) detection reagents, and a transfection reagent;
2-Mammalian Expression Vectors:
A broad array of cloning vectors, that include plasmidic and lentiviral vectors, and CpG-free plasmids, a choice of inducible reporter plasmids, plus an expanding library of human and murine genes, and a wide variety of cellular promoters;
3-Reporter Cells:
A growing collection of functionally validated and mycoplasma-free human and murine cell lines, such as HEK293-, Jurkat-, RAW 264.7- and THP-1-derived cells, that report on one or more pattern recognition receptor (PRR), cytokine, or transcription factor activities using SEAP and/or Lucia luciferase, plus a recently launched line of knockout cells that lack major innate immune sensors or signaling proteins;
4-PRR Ligands:
An expanding collection of agonists and control ligands for all the major PRRs, such as Toll-like receptors (TLRs), NOD-like receptors (NLRs) and cytosolic DNA sensors (CDSs), including ligands of natural and synthetic origin, all screened and validated in-house;
5-Inhibitors:
A wide selection of functionally validated compounds to directly or indirectly block the principal immune (TLR, NLR, CDS) pathways and related signaling pathways;
6-Antibodies and Recombinant Proteins:
A large variety of biologically validated monoclonal and polyclonal antibodies against major human and murine innate immune targets, as well as isotype families of clinically relevant antibodies, plus a selection of recombinant cytokines;
7-Vaccination:
Pre-clinical grade vaccine adjuvants that comprise alum, emulsions, such as CFA and saponin, and PRR ligands, plus various ovalbumin-derived products.
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重庆市寰宇安泰生物科技有限公司
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